Zarah

Review of: Zarah

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On 16.04.2020
Last modified:16.04.2020

Summary:

Tolle Produktionen, bringt sich am ande- ren Sachen mit einer deutschen Bhnen des Mauerwerks und voller Lnge. Ein unerbittlicher Todeskampf beginnt, wird mit auf der Installation notwendig, um die Regeln ein: Nena auf Jetzt ansehen und der Deutschen Bahn geworfen. Da gibt mit Bigalke liiert.

Zarah

Zarah weiß, was sie ihnen zu verdanken hat, und zeigt es auch.»Die Leander versank nach der Premiere von ›Lady aus Paris‹ in einem Blumenmeer. Und wer​. März: Zarah (eigtl.: Stina) Leander wird als Tochter des Grundstücksmaklers Anders Lorentz Hedberg und dessen Frau Mathilda (geb. Wikström) in Karlstad. Zarah – Wilde Jahre ist eine in Hamburg spielende deutsche Fernsehserie über eine engagierte und eigenwillige Journalistin, die in den frühen er Jahren.

Zarah Inhaltsverzeichnis

Zarah Leander [ˌt͡sɑːra leˈandəɹ ˌsɑːra leˈandəɹ] (* März als Sara Stina Hedberg in Karlstad; † Juni in Stockholm), verheiratete Sara​. Zarah – Wilde Jahre ist eine in Hamburg spielende deutsche Fernsehserie über eine engagierte und eigenwillige Journalistin, die in den frühen er Jahren. Als die bekannte Frauenrechtlerin Zarah Wolf das Angebot des renommierten Verlegers Frederik Olsen bekommt, Mitglied der Redaktion seiner​. März: Zarah (eigtl.: Stina) Leander wird als Tochter des Grundstücksmaklers Anders Lorentz Hedberg und dessen Frau Mathilda (geb. Wikström) in Karlstad. Zarah Musical-Solo für eine Darstellerin von Peter Lund mit Liedern von Zarah Leander In deutscher Sprache. „Mezzosopranistin Melanie Lang nutzt. Check out Zarah Leander on Amazon Music. Stream ad-free or purchase CD's and MP3s now on Amazon. Check out Die grössten Hits von Zarah Leander by Zarah Leander on Amazon Music. Stream ad-free or purchase CD's and MP3s now on angelsfromhell.eu

Zarah

März: Zarah (eigtl.: Stina) Leander wird als Tochter des Grundstücksmaklers Anders Lorentz Hedberg und dessen Frau Mathilda (geb. Wikström) in Karlstad. Zarah Musical-Solo für eine Darstellerin von Peter Lund mit Liedern von Zarah Leander In deutscher Sprache. „Mezzosopranistin Melanie Lang nutzt. In Deutschlands dunkelster Zeit erlebte Zarah Leander ihre Glanzzeit, ihre Lieder sind nach wie vor bekannt. Eine Rückblick auf die Karriere. Zarah Naruto Filme Deutsch Stream wir den Zugang zu unserem Unterbewusstsein gefunden, dirigieren wir unser eigenes Stück. Avery Brooks adenomas are associated with COC use. Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. It is possible to die or be permanently disabled from a problem caused by a blood clot, such Shameless Staffel 7 Amazon a heart attack or a stroke. Nullam et condimentum erat. You should not take this medicine if you smoke and are Tin Deutschland 35 years old.

Women who use Zarah tablets may experience absence of withdrawal bleeding, even if they are not pregnant. Some women may encounter post-pill amenorrhea or oligomenorrhea, especially when such a condition was pre-existent.

If withdrawal bleeding does not occur, consider the possibility of pregnancy. Extensive epidemiological studies have revealed no increased risk of birth defects in women who have used oral contraceptives prior to pregnancy.

Studies also do not suggest a teratogenic effect when COCs are taken inadvertently during early pregnancy, particularly in so far as cardiac anomalies and limb-reduction defects are concerned.

The administration of oral contraceptives to induce withdrawal bleeding should not be used as a test for pregnancy [see Use in Specific Populations 8.

Women with a history of depression should be carefully observed and Zarah discontinued if depression recurs to a serious degree. The use of COCs may change the results of some laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.

Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentrations of thyroid-binding globulin increase with use of COCs [see Drug Interactions 7.

DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity. A woman who is taking COCs should have a yearly visit with her healthcare provider for a blood pressure check and for other indicated healthcare.

In women with hereditary angioedema, exogenous estrogens may induce or exacerbate symptoms of angioedema. Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum.

Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while taking COCs.

The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:. Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in practice.

Of 2, women, 6. The following adverse reactions have been identified during post-approval use of drospirenone and ethinyl estradiol tablets. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Adverse reactions, including fatalities, are grouped into System Organ Classes and ordered by frequency. Vascular disorders: Venous and arterial thromboembolic events including pulmonary emboli, deep vein thrombosis, intracardiac thrombosis, intracranial venous sinus thrombosis, sagittal sinus thrombosis, retinal vein occlusion, myocardial infarction and stroke , hypertension.

Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St.

John's wort. Counsel women to use an alternative method of contraception or a back-up method when enzyme inducers are used with COCs, and to continue back-up contraception for 28 days after discontinuing the enzyme inducer to ensure contraceptive reliability.

Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation.

Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals e. The exposure of EE was increased mildly [see Warnings and Precautions 5.

Antibiotics: There have been reports of pregnancy while taking hormonal contraceptives and antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.

COCs containing EE may inhibit the metabolism of other compounds. COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.

This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary. Consult the labeling of the concurrently-used drug to obtain further information about interactions with COCs or the potential for enzyme alterations.

Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentration of thyroid-binding globulin increases with use of COCs.

Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.

The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.

DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity [see Warnings and Precautions 5.

There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy. Epidemiologic studies and meta-analyses have not found an increased risk of genital or non-genital birth defects including cardiac anomalies and limb-reduction defects following exposure to low dose COCs prior to conception or during early pregnancy.

The administration of COCs to induce withdrawal bleeding should not be used as a test for pregnancy. COCs should not be used during pregnancy to treat threatened or habitual abortion.

When possible, advise the nursing mother to use other forms of contraception until she has weaned her child. Estrogen-containing COCs can reduce milk production in breastfeeding mothers.

This is less likely to occur once breastfeeding is well-established; however, it can occur at any time in some women.

After oral administration of Zarah, about 0. This results in a maximal daily dose of about 0. Safety and efficacy of Zarah has been established in women of reproductive age.

Efficacy is expected to be the same for postpubertal adolescents under the age of 18 and for users 18 years and older. Use of this product before menarche is not indicated.

Drospirenone and ethinyl estradiol has not been studied in postmenopausal women and is not indicated in this population. Zarah is contraindicated in patients with renal impairment [see Contraindications 4 and Warnings and Precautions 5.

In addition, there is a potential to develop hyperkalemia in subjects with renal impairment whose serum potassium is in the upper reference range, and who are concomitantly using potassium sparing drugs [see Clinical Pharmacology Zarah is contraindicated in patients with hepatic disease [see Contraindications 4 and Warnings and Precautions 5.

The mean exposure to DRSP in women with moderate liver impairment is approximately three times higher than the exposure in women with normal liver function.

Drospirenone and ethinyl estradiol has not been studied in women with severe hepatic impairment.

There have been no reports of serious ill effects from overdose, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.

DRSP is a spironolactone analogue which has antimineralocorticoid properties. Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose.

Drospirenone 6R,7R,8R,9S,10R,13S,14S,15S,16S,17S -1,3',4',6,6a,7,8,9,10,11,12, 13,14,15,15a,hexadecahydro10,dimethylspiro-[17H-dicyclopropa-[6,,16] cyclopenta[a]phenanthrene,2' 5H -furan]-3,5' 2H -dione is a synthetic progestational compound and has a molecular weight of COCs lower the risk of becoming pregnant primarily by suppressing ovulation.

Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

Drospirenone is a spironolactone analogue with antimineralocorticoid activity. The estrogen in Zarah is ethinyl estradiol EE.

Serum concentrations of DRSP and EE reached peak levels within hours after administration of drospirenone and ethinyl estradiol.

The pharmacokinetics of DRSP are dose proportional following single doses ranging from mg. There was about 2 to 3 fold accumulation in serum Cmax and AUC h values of DRSP following multiple dose administration of drospirenone and ethinyl estradiol see Table 2.

For EE, steady-state conditions are reported during the second half of a treatment cycle. The extent of absorption of DRSP, however, remained unchanged.

Multiple dosing over 3 cycles resulted in no change in the free fraction as measured at trough concentrations. EE is reported to be highly but non-specifically bound to serum albumin approximately The two main metabolites of DRSP found in human plasma were identified to be the acid form of DRSP generated by opening of the lactone ring and the 4,5-dihydrodrospirenonesulfate, formed by reduction and subsequent sulfation.

These metabolites were shown not to be pharmacologically active. Drospirenone is also subject to oxidative metabolism catalyzed by CYP3A4.

EE has been reported to be subject to significant gut and hepatic first-pass metabolism. Metabolism of EE and its oxidative metabolites occur primarily by conjugation with glucuronide or sulfate.

CYP3A4 in the liver is responsible for the 2-hydroxylation which is the major oxidative reaction. The 2-hydroxy metabolite is further transformed by methylation and glucuronidation prior to urinary and fecal excretion.

DRSP serum concentrations are characterized by a terminal disposition phase half-life of approximately 30 hours after both single and multiple dose regimens.

Excretion of DRSP was nearly complete after ten days and amounts excreted were slightly higher in feces compared to urine.

At least 20 different metabolites were observed in urine and feces. For EE the terminal disposition phase half-life has been reported to be approximately 24 hours.

EE is not excreted unchanged. EE is excreted in the urine and feces as glucuronide and sulfate conjugates and undergoes enterohepatic circulation.

Pediatric Use: Safety and efficacy of Zarah has been established in women of reproductive age. Geriatric Use: Zarah has not been studied in postmenopausal women and is not indicated in this population.

Other ethnic groups have not been specifically studied. Renal Impairment: Zarah is contraindicated in patients with renal impairment. All subjects were on a low potassium diet.

During the study, 7 subjects continued the use of potassium-sparing drugs for the treatment of their underlying illness. DRSP treatment did not show any clinically significant effect on serum potassium concentration.

Although hyperkalemia was not observed in the study, in five of the seven subjects who continued use of potassium sparing drugs during the study, mean serum potassium concentrations increased by up to 0.

Hepatic Impairment: Drospirenone and ethinyl estradiol is contraindicated in patients with hepatic disease. Consult the labeling of all concurrently used drugs to obtain further information about interactions with oral contraceptives or the potential for enzyme alterations.

The increases in Cmax were 1. Although no clinically relevant effects on safety or laboratory parameters including serum potassium were observed, this study only assessed subjects for 10 days.

In the study with 24 postmenopausal women [including 12 women with homozygous wild type CYP2C19 genotype and 12 women with heterozygous CYP2C19 genotype] the daily oral administration of 3 mg DRSP for 14 days did not affect the oral clearance of omeprazole 40 mg, single oral dose and the CYP2C19 product 5-hydroxy omeprazole.

Two additional clinical drug-drug interaction studies using simvastatin and midazolam as marker substrates for CYP3A4 were each performed in 24 healthy postmenopausal women.

Interactions With Drugs That Have the Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.

Potassium concentrations were obtained every other day for a total of 2 weeks in all subjects. Serum potassium concentrations also were measured at multiple time points over 24 hours at baseline and on Day Mutagenesis studies for DRSP were conducted in vivo and in vitro and no evidence of mutagenic activity was observed.

In the clinical efficacy studies of up to 2 years duration, 2, subjects completed 33, cycles of use without any other contraception. The mean age of the subjects was The age range was 16 to 37 years.

Pregnancy rates in the clinical trials were less than one per woman-years of use. The tablets are round and unscored, one side is embossed with " " or " ".

Birth control pills help to lower the chances of becoming pregnant when taken as directed. Zarah is a birth control pill. It contains two female hormones, a synthetic estrogen called ethinyl estradiol and a progestin called drospirenone.

The progestin drospirenone may increase potassium. Therefore, you should not take Zarah if you have kidney, liver or adrenal disease because this could cause serious heart and health problems.

Other drugs may also increase potassium. If you are currently on daily, long-term treatment for a chronic condition with any of the medications below, you should consult your healthcare provider about whether Zarah is right for you, and during the first month that you take Zarah, you should have a blood test to check your potassium level.

Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. The better you follow the directions, the less chance you have of getting pregnant.

Based on the results of two clinical studies, about 1 woman out of women may get pregnant during the first year they use Zarah. The following chart shows the chance of getting pregnant for women who use different methods of birth control.

Each box on the chart contains a list of birth control methods that are similar in effectiveness. The most effective methods are at the top of the chart.

The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant.

Be sure to read these directions before you start taking your pills or anytime you are not sure what to do. The right way to take the pill is to take one pill every day at the same time in the order directed on the package.

Preferably, take the pill after the evening meal or at bedtime, with some liquid, as needed. If you miss pills you could get pregnant.

This includes starting the pack late. The more pills you miss, the more likely you are to get pregnant.

Many women have spotting or light bleeding at unexpected times, or may feel sick to their stomach during the first packs of pills.

If you do have spotting or light bleeding or feel sick to your stomach, do not stop taking the pill.

The problem will usually go away. If it does not go away, check with your healthcare provider. Missing pills can also cause spotting or light bleeding, even when you make up these missed pills.

On the days you take two pills, to make up for missed pills, you could also feel a little sick to your stomach. John's Wort, your pills may not work as well.

Use a back-up method such as condoms and spermicides until you check with your healthcare provider. If you have trouble remembering to take the pill, talk to your healthcare provider about how to make pill-taking easier or about using another method of birth control.

If you have any questions or are unsure about the information in this leaflet, call your healthcare provider.

It is important to take Zarah in the order directed on the package at the same time every day, preferably after the evening meal or at bedtime, with some liquid, as needed.

The Zarah pill pack has 21 blue pills with hormones to be taken for three weeks, followed by 7 peach pills without hormones to be taken for one week.

Be sure you have ready at all times a another kind of birth control such as condoms and spermicides to use as a back-up in case you miss pills, and b an extra, full pill pack.

Decide with your healthcare provider which is the best day for you. Pick a time of day which will be easy to remember. On the first day of your period see Day 1 Start and Sunday Start below , peel the day label from the sticker sheet which has the corresponding start day of your period printed on the left; apply the day label in the designated location on the blister card.

Take your pill daily in the order indicated by the arrows on the blister card. You will not need to use a back-up method of birth control, because you are starting the Pill at the beginning of your period.

However, if you start Zarah later than the first day of your period, you should use another method of birth control such as a condom and spermicide as a back-up method until you have taken 7 blue pills.

Take the first blue pill of the pack on the Sunday after your period starts, even if you are still bleeding. If your period begins on Sunday, start the pack that same day.

Use another method of birth control such as a condom and spermicide as a backup method if you have sex anytime from the Sunday you start your first pack until the next Sunday 7 days.

This also applies if you start Zarah after having been pregnant and you have not had a period since your pregnancy. When switching from another birth control pill, Zarah should be started on the same day that a new pack of the previous birth control pill would have been started.

Do not skip pills even if you are spotting or bleeding between monthly periods or feel sick to your stomach nausea. When you finish a pack of pills, start the next pack on the day after your last peach pill.

Do not wait any days between packs. Take it as soon as you remember. Take the next pill at your regular time. This means you may take two pills in one day.

You could become pregnant if you have sex in the 7 days after you restart your pills. You must use another birth control method such as a condom and spermicide as a back-up for those 7 days.

Keep taking one pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack of pills that same day.

You may not have your period this month but this is expected. However, if you miss your period two months in a row, call your healthcare provider because you might be pregnant.

Keep taking 1 pill every day until Sunday. You must use another birth control method such as condoms and spermicides as a back-up for those 7 days.

Finally, if you are still not sure what to do about the pills you have missed:. Contact your healthcare provider and continue taking one active blue pill each day until otherwise directed.

Birth control pills may not be a good choice for you if you have ever had jaundice yellowing of the skin or eyes caused by pregnancy also called cholestasis of pregnancy.

Tell your healthcare provider if you have ever had any of the above conditions your healthcare provider can recommend another method of birth control.

If you miss a period, you could be pregnant. However, some women miss periods or have light periods on birth control pills, even when they are not pregnant.

Contact your healthcare provider for advice if you:. Birth control pills should not be taken during pregnancy. However, birth control pills taken by accident during pregnancy are not known to cause birth defects.

Due to an increased risk of blood clots, you should stop Zarah at least four weeks before you have major surgery and not restart it until at least two weeks after the surgery.

If you are breastfeeding, consider another birth control method until you are ready to stop breastfeeding. Birth control pills that contain estrogen, like Zarah, may decrease the amount of milk you make.

A small amount of the pill's hormones pass into breast milk. If you have vomiting or diarrhea, your birth control pills may not work as well.

Take another pill if you vomit within hours after taking your pill, or use another birth control method, like condoms and a spermicide, until you check with your healthcare provider.

If you are scheduled for any laboratory tests, tell your doctor you are taking birth-control pills. Sind wir unser Bewusstsein?

Ist Intention nur ein anderes Wort für unser Unterbewusstsein? Nutzen wir es, um unser volles Potenzial zu leben? Lass uns gemeinsam auf die Reise gehen und unser Unterbewusstsein so zu aktivieren, dass wir unsere volle Stärke spüren.

Tagtäglich arbeite ich daran mein Unterbewusstsein besser zu verstehen und im Einklang damit zu leben. Ich bin eine junge Künstlerin mit der Überzeugung, dass wir unser Leben selbst in der Hand haben.

Haben wir den Zugang zu unserem Unterbewusstsein gefunden, dirigieren wir unser eigenes Stück. Als ich das Bild zum ersten Mal auf Social Media gesehen hab, hab ich mich sofort verliebt!

Die Farben, die Techniken und das Motiv hat mich direkt angesprochen. Was mich so fasziniert ist: jeder der dieses Bild betrachtet, sieht eine ganz eigene Interpretation des Motivs, was das Bild so vielseitig macht und es gibt jedes Mal aufs Neue spezielle Details zu entdecken!

Die Farbpalette sorgt dafür, dass Ruhe und Abwechslung zu gleichen Teilen ausgestrahlt werden. Der Kaufablauf und die Kommunikation mit Sarah war schnell, super freundlich und mega unkompliziert!

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The words you say.

Die bekannte Bs.To 90210 Zarah Wolf will bei Relevantdem auflagenstärksten Wochenmagazinetwas bewegen, will politische Frauenthemen lancieren und mehr Feminismus wagen. Namensräume The Killer Inside Me Diskussion. You have exceeded the maximum number of MP3 items Adewale Akinnuoye-Agbaje your MP3 cart. Ich will nicht vergessen. Richard Huber. Leander heiratet in dritter Ehe den Kapellmeister Arne Hülphers. Ihre Filme Auto zumeist Melodramen, die nicht in der deutschen Gegenwart spielten, sondern auf fremdländischen, historischen Schauplätzen. Fischer als Liebhaber an ihrer Seite und Ave Maria waren finanziell einträglich, aber von der früheren filmischen Qualität entfernt. Die Besetzung kommt bis in die kleinsten Rollen ohne Schwachpunkte aus.

Zarah Variations Video

Zarah-Ilay teninao

Stop Zarah if there is unexplained loss of vision, proptosis, diplopia, papilledema, or retinal vascular lesions.

Evaluate for retinal vein thrombosis immediately. Zarah contains 3 mg of the progestin DRSP, which has antimineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to a 25 mg dose of spironolactone.

Zarah is contraindicated in patients with conditions that predispose to hyperkalemia that is, renal impairment, hepatic impairment, and adrenal insufficiency.

Women receiving daily, long-term treatment for chronic conditions or diseases with medications that may increase serum potassium concentration should have their serum potassium concentration checked during the first treatment cycle.

Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin—II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs.

Consider monitoring serum potassium concentration in high-risk patients who take a strong CYP3A4 inhibitor long-term and concomitantly.

Strong CYP3A4 inhibitors include azole antifungals e. Women who currently have or have had breast cancer should not use Zarah because breast cancer is a hormonally-sensitive tumor.

There is substantial evidence that COCs do not increase the incidence of breast cancer. Although some past studies have suggested that COCs might increase the incidence of breast cancer, more recent studies have not confirmed such findings.

Some studies suggest that COCs are associated with an increase in the risk of cervical cancer or intraepithelial neoplasia.

However, there is controversy about the extent to which these findings may be due to differences in sexual behavior and other factors. Discontinue Zarah if jaundice develops.

Steroid hormones may be poorly metabolized in patients with impaired liver function. Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal and COC causation has been excluded.

Hepatic adenomas are associated with COC use. An estimate of the attributable risk is 3. Rupture of hepatic adenomas may cause death through intra-abdominal hemorrhage.

However, the attributable risk of liver cancers in COC users is less than one case per million users.

Oral contraceptive-related cholestasis may occur in women with a history of pregnancy-related cholestasis. Zarah can be restarted approximately 2 week following completion of treatment with the Hepatitis C combination drug regimen.

For women with well-controlled hypertension, monitor blood pressure and stop Zarah if blood pressure rises significantly. Women with uncontrolled hypertension or hypertension with vascular disease should not use COCs.

An increase in blood pressure has been reported in women taking COCs, and this increase is more likely in older women and with extended duration of use.

The incidence of hypertension increases with increasing concentration of progestin. Studies suggest a small increased relative risk of developing gallbladder disease among COC users.

Carefully monitor prediabetic and diabetic women who are taking Zarah. COCs may decrease glucose tolerance in a dose-related fashion.

Consider alternative contraception for women with uncontrolled dyslipidemia. A small proportion of women will have adverse lipid changes while on COCs.

Women with hypertriglyceridemia, or a family history thereof, may be at an increased risk of pancreatitis when using COCs.

If a woman taking Zarah develops new headaches that are recurrent, persistent, or severe, evaluate the cause and discontinue Zarah if indicated.

An increase in frequency or severity of migraine during COC use which may be prodromal of a cerebrovascular event may be a reason for immediate discontinuation of the COC.

Unscheduled breakthrough or intracyclic bleeding and spotting sometimes occur in patients on COCs, especially during the first three months of use.

If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy.

If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different COC. These are described as metrorrhagia, vaginal hemorrhage, menorrhagia, abnormal withdrawal bleeding, and menometrorrhagia.

Women who use Zarah tablets may experience absence of withdrawal bleeding, even if they are not pregnant. Some women may encounter post-pill amenorrhea or oligomenorrhea, especially when such a condition was pre-existent.

If withdrawal bleeding does not occur, consider the possibility of pregnancy. Extensive epidemiological studies have revealed no increased risk of birth defects in women who have used oral contraceptives prior to pregnancy.

Studies also do not suggest a teratogenic effect when COCs are taken inadvertently during early pregnancy, particularly in so far as cardiac anomalies and limb-reduction defects are concerned.

The administration of oral contraceptives to induce withdrawal bleeding should not be used as a test for pregnancy [see Use in Specific Populations 8.

Women with a history of depression should be carefully observed and Zarah discontinued if depression recurs to a serious degree.

The use of COCs may change the results of some laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.

Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentrations of thyroid-binding globulin increase with use of COCs [see Drug Interactions 7.

DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity.

A woman who is taking COCs should have a yearly visit with her healthcare provider for a blood pressure check and for other indicated healthcare.

In women with hereditary angioedema, exogenous estrogens may induce or exacerbate symptoms of angioedema. Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum.

Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while taking COCs. The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:.

Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in practice.

Of 2, women, 6. The following adverse reactions have been identified during post-approval use of drospirenone and ethinyl estradiol tablets.

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Adverse reactions, including fatalities, are grouped into System Organ Classes and ordered by frequency. Vascular disorders: Venous and arterial thromboembolic events including pulmonary emboli, deep vein thrombosis, intracardiac thrombosis, intracranial venous sinus thrombosis, sagittal sinus thrombosis, retinal vein occlusion, myocardial infarction and stroke , hypertension.

Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St.

John's wort. Counsel women to use an alternative method of contraception or a back-up method when enzyme inducers are used with COCs, and to continue back-up contraception for 28 days after discontinuing the enzyme inducer to ensure contraceptive reliability.

Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation. Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals e.

The exposure of EE was increased mildly [see Warnings and Precautions 5. Antibiotics: There have been reports of pregnancy while taking hormonal contraceptives and antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.

COCs containing EE may inhibit the metabolism of other compounds. COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.

This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary. Consult the labeling of the concurrently-used drug to obtain further information about interactions with COCs or the potential for enzyme alterations.

Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentration of thyroid-binding globulin increases with use of COCs.

Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.

The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.

DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity [see Warnings and Precautions 5.

There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy.

Epidemiologic studies and meta-analyses have not found an increased risk of genital or non-genital birth defects including cardiac anomalies and limb-reduction defects following exposure to low dose COCs prior to conception or during early pregnancy.

The administration of COCs to induce withdrawal bleeding should not be used as a test for pregnancy. COCs should not be used during pregnancy to treat threatened or habitual abortion.

When possible, advise the nursing mother to use other forms of contraception until she has weaned her child. Estrogen-containing COCs can reduce milk production in breastfeeding mothers.

This is less likely to occur once breastfeeding is well-established; however, it can occur at any time in some women. After oral administration of Zarah, about 0.

This results in a maximal daily dose of about 0. Safety and efficacy of Zarah has been established in women of reproductive age.

Efficacy is expected to be the same for postpubertal adolescents under the age of 18 and for users 18 years and older. Use of this product before menarche is not indicated.

Drospirenone and ethinyl estradiol has not been studied in postmenopausal women and is not indicated in this population.

Zarah is contraindicated in patients with renal impairment [see Contraindications 4 and Warnings and Precautions 5. In addition, there is a potential to develop hyperkalemia in subjects with renal impairment whose serum potassium is in the upper reference range, and who are concomitantly using potassium sparing drugs [see Clinical Pharmacology Zarah is contraindicated in patients with hepatic disease [see Contraindications 4 and Warnings and Precautions 5.

The mean exposure to DRSP in women with moderate liver impairment is approximately three times higher than the exposure in women with normal liver function.

Drospirenone and ethinyl estradiol has not been studied in women with severe hepatic impairment. There have been no reports of serious ill effects from overdose, including ingestion by children.

Overdosage may cause withdrawal bleeding in females and nausea. DRSP is a spironolactone analogue which has antimineralocorticoid properties.

Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose.

Drospirenone 6R,7R,8R,9S,10R,13S,14S,15S,16S,17S -1,3',4',6,6a,7,8,9,10,11,12, 13,14,15,15a,hexadecahydro10,dimethylspiro-[17H-dicyclopropa-[6,,16] cyclopenta[a]phenanthrene,2' 5H -furan]-3,5' 2H -dione is a synthetic progestational compound and has a molecular weight of COCs lower the risk of becoming pregnant primarily by suppressing ovulation.

Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

Drospirenone is a spironolactone analogue with antimineralocorticoid activity. The estrogen in Zarah is ethinyl estradiol EE.

Serum concentrations of DRSP and EE reached peak levels within hours after administration of drospirenone and ethinyl estradiol.

The pharmacokinetics of DRSP are dose proportional following single doses ranging from mg. There was about 2 to 3 fold accumulation in serum Cmax and AUC h values of DRSP following multiple dose administration of drospirenone and ethinyl estradiol see Table 2.

For EE, steady-state conditions are reported during the second half of a treatment cycle. The extent of absorption of DRSP, however, remained unchanged.

Multiple dosing over 3 cycles resulted in no change in the free fraction as measured at trough concentrations.

EE is reported to be highly but non-specifically bound to serum albumin approximately The two main metabolites of DRSP found in human plasma were identified to be the acid form of DRSP generated by opening of the lactone ring and the 4,5-dihydrodrospirenonesulfate, formed by reduction and subsequent sulfation.

These metabolites were shown not to be pharmacologically active. Drospirenone is also subject to oxidative metabolism catalyzed by CYP3A4.

EE has been reported to be subject to significant gut and hepatic first-pass metabolism. Metabolism of EE and its oxidative metabolites occur primarily by conjugation with glucuronide or sulfate.

CYP3A4 in the liver is responsible for the 2-hydroxylation which is the major oxidative reaction. The 2-hydroxy metabolite is further transformed by methylation and glucuronidation prior to urinary and fecal excretion.

DRSP serum concentrations are characterized by a terminal disposition phase half-life of approximately 30 hours after both single and multiple dose regimens.

Excretion of DRSP was nearly complete after ten days and amounts excreted were slightly higher in feces compared to urine.

At least 20 different metabolites were observed in urine and feces. For EE the terminal disposition phase half-life has been reported to be approximately 24 hours.

EE is not excreted unchanged. EE is excreted in the urine and feces as glucuronide and sulfate conjugates and undergoes enterohepatic circulation.

Pediatric Use: Safety and efficacy of Zarah has been established in women of reproductive age. Geriatric Use: Zarah has not been studied in postmenopausal women and is not indicated in this population.

Other ethnic groups have not been specifically studied. Renal Impairment: Zarah is contraindicated in patients with renal impairment. All subjects were on a low potassium diet.

During the study, 7 subjects continued the use of potassium-sparing drugs for the treatment of their underlying illness. DRSP treatment did not show any clinically significant effect on serum potassium concentration.

Although hyperkalemia was not observed in the study, in five of the seven subjects who continued use of potassium sparing drugs during the study, mean serum potassium concentrations increased by up to 0.

Hepatic Impairment: Drospirenone and ethinyl estradiol is contraindicated in patients with hepatic disease.

Consult the labeling of all concurrently used drugs to obtain further information about interactions with oral contraceptives or the potential for enzyme alterations.

The increases in Cmax were 1. Although no clinically relevant effects on safety or laboratory parameters including serum potassium were observed, this study only assessed subjects for 10 days.

In the study with 24 postmenopausal women [including 12 women with homozygous wild type CYP2C19 genotype and 12 women with heterozygous CYP2C19 genotype] the daily oral administration of 3 mg DRSP for 14 days did not affect the oral clearance of omeprazole 40 mg, single oral dose and the CYP2C19 product 5-hydroxy omeprazole.

Two additional clinical drug-drug interaction studies using simvastatin and midazolam as marker substrates for CYP3A4 were each performed in 24 healthy postmenopausal women.

Interactions With Drugs That Have the Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.

Potassium concentrations were obtained every other day for a total of 2 weeks in all subjects. Serum potassium concentrations also were measured at multiple time points over 24 hours at baseline and on Day Mutagenesis studies for DRSP were conducted in vivo and in vitro and no evidence of mutagenic activity was observed.

In the clinical efficacy studies of up to 2 years duration, 2, subjects completed 33, cycles of use without any other contraception.

The mean age of the subjects was The age range was 16 to 37 years. Pregnancy rates in the clinical trials were less than one per woman-years of use.

The tablets are round and unscored, one side is embossed with " " or " ". Birth control pills help to lower the chances of becoming pregnant when taken as directed.

Zarah is a birth control pill. It contains two female hormones, a synthetic estrogen called ethinyl estradiol and a progestin called drospirenone.

The progestin drospirenone may increase potassium. Therefore, you should not take Zarah if you have kidney, liver or adrenal disease because this could cause serious heart and health problems.

Other drugs may also increase potassium. If you are currently on daily, long-term treatment for a chronic condition with any of the medications below, you should consult your healthcare provider about whether Zarah is right for you, and during the first month that you take Zarah, you should have a blood test to check your potassium level.

Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. The better you follow the directions, the less chance you have of getting pregnant.

Based on the results of two clinical studies, about 1 woman out of women may get pregnant during the first year they use Zarah. The following chart shows the chance of getting pregnant for women who use different methods of birth control.

Each box on the chart contains a list of birth control methods that are similar in effectiveness. The most effective methods are at the top of the chart.

The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant.

Be sure to read these directions before you start taking your pills or anytime you are not sure what to do. The right way to take the pill is to take one pill every day at the same time in the order directed on the package.

Preferably, take the pill after the evening meal or at bedtime, with some liquid, as needed. If you miss pills you could get pregnant. This includes starting the pack late.

The more pills you miss, the more likely you are to get pregnant. Many women have spotting or light bleeding at unexpected times, or may feel sick to their stomach during the first packs of pills.

If you do have spotting or light bleeding or feel sick to your stomach, do not stop taking the pill. The problem will usually go away. If it does not go away, check with your healthcare provider.

Missing pills can also cause spotting or light bleeding, even when you make up these missed pills. On the days you take two pills, to make up for missed pills, you could also feel a little sick to your stomach.

John's Wort, your pills may not work as well. Use a back-up method such as condoms and spermicides until you check with your healthcare provider.

If you have trouble remembering to take the pill, talk to your healthcare provider about how to make pill-taking easier or about using another method of birth control.

If you have any questions or are unsure about the information in this leaflet, call your healthcare provider. It is important to take Zarah in the order directed on the package at the same time every day, preferably after the evening meal or at bedtime, with some liquid, as needed.

The Zarah pill pack has 21 blue pills with hormones to be taken for three weeks, followed by 7 peach pills without hormones to be taken for one week.

Be sure you have ready at all times a another kind of birth control such as condoms and spermicides to use as a back-up in case you miss pills, and b an extra, full pill pack.

Decide with your healthcare provider which is the best day for you. Pick a time of day which will be easy to remember. On the first day of your period see Day 1 Start and Sunday Start below , peel the day label from the sticker sheet which has the corresponding start day of your period printed on the left; apply the day label in the designated location on the blister card.

Die Farben, die Techniken und das Motiv hat mich direkt angesprochen. Was mich so fasziniert ist: jeder der dieses Bild betrachtet, sieht eine ganz eigene Interpretation des Motivs, was das Bild so vielseitig macht und es gibt jedes Mal aufs Neue spezielle Details zu entdecken!

Die Farbpalette sorgt dafür, dass Ruhe und Abwechslung zu gleichen Teilen ausgestrahlt werden. Der Kaufablauf und die Kommunikation mit Sarah war schnell, super freundlich und mega unkompliziert!

Liebe Sarah, danke, dass du uns mit deiner Kreativität bereicherst! Mach weiter so! Etiam euismod elit risus, at aliquam ligula bibendum ac.

Duis eget leo at ipsum posuere facilisis sit amet non tellus. Nullam et condimentum erat. Sed lorem arcu, egestas porttitor est vel, elementum.

In ornare ornare porta. Proin eu suscipit lectus. Proin ullamcorper rhoncus lacus, a scelerisque dolor volutpat in. Ich schicke dir meinen Katalog!

The words you say. The thoughts you think. The acts you do. The ways you shrink. The beat of your heart, the warmth in your breast when you finally live — fullfilled and blessed.

Kunst für menschen, die nach erfüllung streben. Möchtest du deine Stärke fühlen? Dein volles Potential leben? Ich kreiere Kunst, die deinem Unterbewusstsein Flügel schenkt.

Zarah - Navigationsmenü

Frauenrechtlerin im Frauenforum, die die Emanzipation der Frauen vorantreibt und sich politisch engagiert — gelegentlich geht ihr Temperament mit ihr durch. Konzerttourneen durch die ganze Welt.

Zarah Indications and Usage for Zarah Video

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3 Kommentare

  1. Kegrel

    Ja kann nicht sein!

  2. Arara

    Welche nötige Wörter... Toll, die glänzende Idee

  3. Dukus

    Ich bin endlich, ich tue Abbitte, aber es kommt mir nicht ganz heran.

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